Commissioned on 24 September 1920, the destroyer REUBEN JAMES (DD 245) served in the Atlantic Fleet, operating in the Adriatic, Mediterranean, and off Nicaragua, before decommissioning at Philadelphia, Pennsylvania, on 20 January 1931.
She recommissioned on 9 March 1932, and upon the outbreak of war in Europe in September 1939 she joined the Neutrality Patrol, guarding the Atlantic and Caribbean approaches to the American coast. In March 1941 REUBEN JAMES joined the convoy escort force established to promote the safe arrival of war materials to Britain. This escort force guarded convoys as far as Iceland, where they became the responsibility of British escorts.
Based at Hvalfjordur, Iceland, she sailed from Argentia, Newfoundland, on 23 October 1941, with four other destroyers to escort eastbound convoy HX-156.
At about 0525 on 31 October 1941, REUBEN JAMES was torpedoed by German submarine U-562. Her magazine exploded, and she sank quickly. Forty-four of the crew survived, and 115 died. REUBEN JAMES was the first U.S. Navy ship sunk by hostile action in World War II.